Correlation between serum uric acid/high density lipoprotein cholesterol and carotid atherosclerosis in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.02.002
- VernacularTitle:2型糖尿病患者血尿酸/高密度脂蛋白胆固醇比值与颈动脉粥样硬化相关性的研究
- Author:
Chongzhou DONG
1
;
Haiquan HUANG
;
Jielou ZHANG
;
Lili XIA
;
Wan ZHOU
;
Shandong YE
Author Information
1. 244000 铜陵市人民医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Serum uric acid/high density lipoprotein cholesterol;
Carotid atherosclerosis
- From:
Chinese Journal of Diabetes
2025;33(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum uric acid/high density lipoprotein cholesterol(UHR)and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 322 patients with T2DM admitted to Department of Endocrinology,Tongling People's Hospital were enrolled in this study from November 2021 to March 2023.They were divided into CAS group(n=165)and T2DM group(n=157)according to whether accompanied with CAS.The medical history,physical examination,biochemical examination and UHR were compared between the two groups.Results Compared with T2DM group,the age,SBP,TG,Scr,Cys-C,Hcy,SUA and UHR in CAS group were increased(P<0.01),while HDL-C and HbA1c were decreased(P<0.05 or P<0.01).Pearson or Spearman correlation analysis showed that TG,Scr and Hcy were correlated with UHR(P<0.01).Logistic regression analysis showed that UHR,age and SBP were the independent risk factors of CAS in T2DM patients.ROC curve analysis showed that the sensitivity and specificity of UHR in predicting CAS were 82.40%and 73.90%.Conclusions UHR is the risk factor of CAS in T2DM patients and has a certain predictive value for CAS.
