Application of inhaled levosimendan in pulmonary hypertension complicated with right heart failure
10.12092/j.issn.1009-2501.2025.08.017
- VernacularTitle:吸入左西孟旦在肺动脉高压合并右心衰中的应用
- Author:
Wanyu LIU
1
;
Tongwen SUN
;
Zhengrong MAO
Author Information
1. 河南中医药大学第一附属医院急诊科,河南中医药大学第一附属医院急危重症医学部,郑州 450000,河南
- Publication Type:Journal Article
- Keywords:
pulmonary hypertension;
right heart failure;
inhaled levosimendan;
efficacy;
safety
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(8):1147-1152
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension(PH)is a seri-ous disease characterized by abnormally high pul-monary arterial pressure(PAP),which leads to in-creased cardiac burden and may eventually lead to right heart failure.Levosimendan,as a calcium sen-sitizer,has the dual role of enhancing cardiac con-striction force and promoting vascular dilation.It shows a good prospect in the treatment of PH com-bined with right heart failure by reducing PAP,in-creasing RV contractile force and reducing anterior and posterior cardiac load without increasing myo-cardial oxygen consumption.Since it does not in-crease the intracellular Ca2+concentration,it avoids the arrhythmia-inducing,reduced coronary perfu-sion and other side effects of other positive inotro-pic drugs.At present,levosimandan is mainly trans-fused intravenically,which may lead to systemic hy-potension,arrhythmia and other side effects,while inhalation administration can reduce the occur-rence of adverse reactions,but its effectiveness and safety in the treatment of PH combined with right heart failure remains to be studied.The pur-pose of this review was to investigate the role of in-haled levosimendan in PH combined with right heart failure.
