Relationship between serum ING5 levels and recurrence after endoscopic submucosal dissection in early gastric cancer patients
- VernacularTitle:血清生长抑制蛋白家族成员5水平与早期胃癌患者内镜黏膜下剥离术后复发的关系
- Author:
Guodong LI
1
Author Information
- Publication Type:Journal Article
- Keywords: early gastric cancer; inhibitor of growth family member 5(ING5); degree of differentiation; invasion depth; endoscopic submucosal dissection(ESD)
- From: China Journal of Endoscopy 2025;31(2):70-75
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the relationship between serum inhibitor of growth family member 5(ING5)expression levels and postoperative recurrence after endoscopic submucosal dissection(ESD)in early gastric cancer patients.Methods 96 patients of early gastric cancer(study group)who underwent ESD surgery from May 2017 to May 2019,while 96 healthy patients individuals who underwent physical examinations during the same period(control group).Real time fluorescent quantitative polymerase chain reaction(qRT-PCR)was used to detect the ING5 expression level.Analysis of influencing factors through multivariate Logistic regression.Results The serum ING5 expression level in the study group was significantly lower than that in the control group(P<0.05);The serum ING5 expression level was related to the degree of differentiation and depth of infiltration(P<0.05);The proportion of moderate differentiation and submucosal infiltration depth in gastric cancer tissue in the recurrent group of gastric cancer patients after ESD surgery was significantly higher than those in the non recurrent group(P<0.05);ING5<0.75,moderate differentiation and submucosal infiltration depth were independent risk factors for postoperative recurrence in early gastric cancer patients undergoing ESD surgery(P<0.05).Conclusion The expression of ING5 is down-regulated in the serum of patients with early gastric cancer,and is an influencing factor of postoperative recurrence of ESD.It can be used as a tumor suppressor gene marker in clinical research.
