Research status of traditional Chinese medicine regulating endoplasmic reticulum stress in the treatment of osteoporosis
10.13699/j.cnki.1001-6821.2024.24.025
- VernacularTitle:中医药调控内质网应激治疗骨质疏松症的研究现状
- Author:
Ting-ting CAO
1
;
Min BAI
;
Zhan-dong WANG
;
Feng-zhe YAN
;
Wen-jing SONG
;
Chao GUO
;
Yong-feng WANG
;
Bing SONG
;
Yan-ying ZHANG
Author Information
1. 甘肃中医药大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
osteoporosis;
endoplasmic reticulum stress;
osteoblast;
osteoclast;
mesenchymal stem cells
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(24):3643-3647
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis(OP)is a bone-related disease characterized by an imbalance between bone resorption and bone formation.Recent studies have shown that endoplasmic reticulum stress(ERS)plays an important role in the pathogenesis of OP.On the one hand,moderate ERS can regulate the differentiation of mesenchymal stem cells,osteoblasts and osteoclasts through multiple signaling pathways to promote bone homeostasis.On the other hand,excessive ERS can induce apoptosis of bone-related cells through various ways to disrupt bone homeostasis.Traditional Chinese medicine monomer and compound have significant therapeutic effect on OP.Recent studies have found that regulating ERS is one of the important mechanisms of effective treatment of OP by traditional Chinese medicine.From the perspective of ER stress,many studies have explored the mechanism of action in the treatment of OP by Chinese medicine.In this paper,through analyzing and summarizing the literature at home and abroad in recent years,the relevant studies on the involvement of ERS process in osteoporosis and the studies on the treatment of OP by Chinese medicine ERS process were reviewed.To further reveal the involvement of ERS process in the pathogenesis of osteoporosis and the regulatory role of traditional Chinese medicine.
