Disease burden attributable to preterm birth and low birth weight in China, 1990-2021: temporal trends and projections
10.3760/cma.j.cn113903-20250430-00232
- VernacularTitle:1990年至2021年我国可归因于早产与低出生体重的疾病负担变化及趋势
- Author:
Xue LENG
1
;
Wenyan XIAO
Author Information
1. 安徽医科大学第一附属医院妇产科，合肥 230022
- Publication Type:Journal Article
- Keywords:
Preterm birth;
Low birth weight;
Incidence rate;
Mortality;
Disease burden
- From:
Chinese Journal of Perinatal Medicine
2025;28(8):646-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the temporal trends and projections in disease burden attributable to preterm birth and low birth weight (PBLBW) in China from 1990 to 2021, providing evidence for prevention strategies.Methods:Using Global Burden of Disease (GBD) 2021 data, deaths, disability-adjusted life years (DALYs), and age-standardized rates (ASR) related to PBLBW were calculated. Joinpoint regression analyzed temporal trends, disease-specific impacts, sex/age disparities, and comparisons with socio-demographic index (SDI) regions. An autoregressive integrated moving average (ARIMA) model projected future trends.Results:In 2021, age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) for PBLBW were 3.89/100 000 and 413.24 years/100 000, respectively, which demonstrated a significant decline from 1990 levels (21.80/100 000 and 2 027.96 years/100 000), with average annual percentage changes (AAPC) of－5.39 and－5.03. Male burden exceeded female in 2021 (ASMR: 4.35/100 000 vs. 3.36/100 000; ASDR: 459.48 years/100 000 vs. 359.55 years/100 000). Preterm birth dominated PBLBW-related mortality and DALYs in 2021 (ASMR: 2.65/100 000; ASDR: 301.50 years/100 000). ASMR and ASDR of China in 2021 were lower than that of low-, low-middle-, and middle-SDI regions and global levels, with greater declines during 1990-2021 than that of global levels and all SDI regions. Projections indicate continued decline to 2030 (ASMR: 1.63/100 000; ASDR: 212.62 years/100 000). Conclusion:China achieved substantial reductions in PBLBW-related disease burden, although persistent gender disparities and methodological limitations in data collection necessitate further strengthening of the perinatal healthcare system.
