UBE2O:A Unique Ubiquitin-conjugating Enzyme with Diverse Biological and Pathophysiological Activities
10.13865/j.cnki.cjbmb.2025.03.1515
- VernacularTitle:UBE2O:兼具E2/E3活性的多功能泛素结合酶在多种生物学与病理生理过程中的独特作用
- Author:
Chen-Yu MAO
1
;
Ya-Li WANG
;
Xin-Liang MAO
Author Information
1. 广东省蛋白质修饰与降解重点实验室,基础医学院,广州医科大学,广州 511436
- Publication Type:Journal Article
- Keywords:
protein ubiquitylation;
ubiquitin-conjugating enzyme E2O(UBE2O);
monoubiquitylation;
multi-monoubiquitylation;
polyubiquitylation
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(6):783-797
- CountryChina
- Language:Chinese
-
Abstract:
UBE2O is a distinctive ubiquitin-conjugating enzyme characterized by its large size(1 292 residues)and dual E2/E3 enzymatic activities,enabling diverse ubiquitylation types.Unlike typical E2 enzymes(150～200 residues),UBE2O's multifunctionality allows it to regulate substrate degradation,subcellular localization,and functional modulation.Emerging studies highlight its critical roles in protein quality control,erythroid differentiation,metabolic regulation,and maintenance of circadian rhythm.Dysregulation of UBE2O is implicated in various diseases,including cancers,neurodegenerative disor-ders,and metabolic diseases.This review extensively discusses the unique structural features,diverse bi-ological functions,and pathological roles of UBE2O,as well as its therapeutic potential for associated dis-eases.
