Study on quantitative evaluation of risk factors and correlation of type 2 diabetes mellitus complicated with metabolic fatty liver disease by instantaneous elastic imaging of liver FibroScan
10.3969/j.issn.1006-6187.2025.02.010
- VernacularTitle:肝脏瞬时弹性成像技术定量评价2型糖尿病合并代谢相关脂肪性肝病发病危险因素及相关性的研究
- Author:
Zhenyu YANG
1
;
Minna HAN
;
Chen ZHAO
;
Chang TAN
;
Jing CHEN
Author Information
1. 518116 深圳大学附属华南医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
FibroScan;
Metabolic associated fatty liver disease;
Risk factors
- From:
Chinese Journal of Diabetes
2025;33(2):131-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitatively measure the liver fat content and liver fibrosis degree in patients with type 2 diabetes mellitus(T2DM)using liver transient elastography(FibroScan)and analyze the risk factors for metabolism-related fatty liver disease(MAFLD).Methods A retrospective analysis was conducted on the clinical data of 258 patients with T2DM admitted to The Department of Endocrinology,Harbin First Hospital from August 2017 to November 2020.The patients were divided into the simple T2DM group(n=41)and the MAFLD(n=217)group based on whether they had MAFLD.Both groups were assessed using the FibroScan 502 system to measure liver fat content(CAP)and liver fibrosis degree(LSM).General information,TC,TG,LDL-C,HDL-C,FPG,HbA1c,FC-P,FIns,and liver function(AST,ALT,GGT)were compared between the two groups.Results BMI,TG,FC-P,FIns,AST,CAP,and LSM were significantly higher in the MAFLD group than in the simple T2DM group(P<0.05).Pearson phase analysis showed that the DM duration,TG,FC-P and LSM were positively correlated with CAP(P<0.05),while TG,AST and CAP were positively correlated with LSM(P<0.05).Logistic regression analysis revealed that BMI,TG,FC-P,CAP,and LSM were risk factors for T2DM combined with MAFLD.Conclusions Elevated BMI,TG,FC-P,CAP,and LSM are risk factors for the onset of T2DM combined with MAFLD.Additionally,TG is a common factor for the increase in CAP and LSM.FibroScan measurement of CAP and LSM values can quantitatively reveal the liver lesion status in patients with T2DM.
