Percutaneous intrauterine laser ablation for giant hybrid pulmonary lesion in a fetus
10.3760/cma.j.cn113903-20250206-00055
- VernacularTitle:经皮宫内激光消融治疗胎儿巨大混合性肺部病变1例
- Author:
Xin ZHAO
1
;
Dan CHEN
1
;
Wei HE
1
;
Lishuang SHI
1
;
Jing WU
1
Author Information
1. 广东省妇幼保健院产前诊断中心，广州 511442
- Publication Type:Journal Article
- Keywords:
Bronchopulmonary sequestration;
Congenital cystic adenomatoid malformation;
Intrauterine therapy;
Laser ablation;
Hybrid pulmonary lesions
- From:
Chinese Journal of Perinatal Medicine
2025;28(8):689-692
- CountryChina
- Language:Chinese
-
Abstract:
This report detailed a case of intrauterine intervention for fetal left-sided congenital cystic adenomatoid malformation with intralobar pulmonary sequestration. The mother had no significant medical history. Ultrasound at 22 gestational weeks showed a giant cystic-solid thoracic mass [32 mm×46 mm×61 mm; congenital pulmonary airway malformation volume ratio (CVR) 2.57], and the diagnosis was congenital cystic adenomatoid malformation complicated by intralobar pulmonary sequestration. After disease progression despite one course of antenatal corticosteroids (55 mm×47 mm×56 mm; CVR 3.33), ultrasound-guided percutaneous intrauterine laser ablation was performed at 24 +6 weeks to precisely coagulate the lesion's dominant feeding artery (confirmed by Doppler). Postoperatively, the mass showed progressive regression with normalized hemodynamic parameters. The infant was delivered vaginally at 37 weeks of gestation. The infant underwent resection of residual left lower lung lesions at five months of age, with normal cardiopulmonary function and developmental milestones confirmed at 15-month follow-up.
