Predictive Value of Time Within the Target Range of Glucose and HbA1c Detection in T2DM Patients for Macroangiopathy in Diabetes
10.3969/j.issn.1671-7414.2025.04.029
- VernacularTitle:T2DM患者葡萄糖目标范围内时间和HbA1c检测对糖尿病大血管病变的预测价值分析
- Author:
Yun LUO
1
;
Gaofen HE
1
;
Qing GUO
1
Author Information
1. 上海市嘉定区安亭医院内分泌科,上海 201805
- Publication Type:Journal Article
- Keywords:
time within the target range of glucose;
glycated hemoglobin;
type 2 diabetes;
diabetes macroangiopathy
- From:
Journal of Modern Laboratory Medicine
2025;40(4):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of time within the target range of glucose(TIR)and glycosylated hemoglobin(HbA1c)in type 2 diabetes(T2DM)patients with macroangiopathy.Methods 110 T2DM patients in Anting Hospital,Jiading District,Shanghai from February 2022 to February 2024 were selected.They were divided into two groups according to whether they were complicated with diabetes macroangiopathy.42 patients with diabetes macroangiopathy were set as the lesion group,and 68 patients without diabetes macroangiopathy were set as the non lesion group.The TIR and HbA1c of the two groups were compared to analyze the risk factors of T2DM complicated with diabetes macroangiopathy by Logistic regression,draw the receiver operating characteristic curve(ROC),and analyze the predictive efficacy of TIR and HbA1c on T2DM complicated with diabetes macroangiopathy.Results Compared with the non diseased group,the TIR of the diseased group(50.64%±3.62%vs 69.82%±5.14%)decreased,while HbA1c(9.02%±1.16%vs 7.29%±1.08%)increased,with statistically significant differences(t=21.144,7.934,all P<0.001).TIR,HbA1c,smoking history,systolic pressure(SBP),low density lipoprotein cholesterol(LDL-C)could be a risk factor for T2DM patients complicated with diabetes macroangiopathy(Waldχ2=5.648～10.516,all P<0.05).When the optimal threshold value of TIR and HbA1c were 59.32%and 8.26%,respectively,the area under curve(AUC)predicted by TIR and HbA1c jointly for T2DM patients with diabetes macroangiopathy which was greater than that by a single test with statistically significant difference(Z=2.728,2.306,all P<0.05).Conclusion The decrease of TIR and the increase of HbA1c are closely related to diabetes macroangiopathy in T2DM patients,and they may be a risk factor for T2DM patients complicated with diabetes macroangiopathy.The combined detection of TIR and HbA1c can improve the prediction sensitivity of diabetes macroangiopathy.
