Correlation between triglyceride glucose index and the risk of diabetic kidney disease in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.02.009
- VernacularTitle:甘油三酯-葡萄糖指数与2型糖尿病患者肾脏疾病相关性的研究
- Author:
Jinjin ZHAO
1
;
Yinzhen PI
;
Li HU
Author Information
1. 410005 长沙市第一医院内分泌代谢科
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Insulin resistance;
Triglyceride/high density lipoprotein cholesterol ratio;
Triglyceride glucose index;
Triglyceride glucose-body mass index;
Metabolic score for insulin resistance
- From:
Chinese Journal of Diabetes
2025;33(2):125-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between four metabolic indices reflecting insulin resistance(IR)and the risk of diabetic kidney disease(DKD)in patients with type 2 diabetes mellitus(T2DM).Methods 157 T2DM patients with DKD(DKD group)and 198 T2DM patients(T2DM group)were included in our study.The general data and clinical indicators were collected.Triglyceride/high density lipoprotein cholesterol ratio(TG/HDL-C),triglyceride glucose(TyG)index,triglyceride glucose-body mass index(TyG-BMI)and metabolic score for IR(METS-IR)were calculated.Results Compared with T2DM group,TG/HDL-C,TyG index,TyG-BMI and METS-IR in DKD group were significantly increased(P<0.05).Logistic regression analysis showed that TyG index(OR=8.303,95%CI 1.787～38.573,P=0.007)was an independent risk factor for DKD.The risk of DKD in the fourth quantile of TyG index group was 5.652 times than the first quantile group(P<0.05).ROC curve analysis showed that when the cutoff value of TyG index was 9.03,its sensitivity and specificity for predicting DKD were 56.7%and 71.7%,respectively.Conclusions Among the four simple IR indicators,TyG index is an independent risk factor for the occurrence of DKD in T2DM patients.Increased TyG index indicates increased UACR level and high risk of DKD.
