Research progress of neuroimmunology on elderly patients with malignant tumor and sarcopenia
10.3969/j.issn.1672-8467.2025.04.016
- VernacularTitle:老年恶性肿瘤患者合并肌少症的神经免疫学研究进展
- Author:
Zi-yu SHEN
1
;
Jun-long SUN
;
Yong-jun ZHENG
Author Information
1. 复旦大学附属华东医院麻醉科 上海 200040
- Publication Type:Journal Article
- Keywords:
malignant tumor;
sarcopenia;
cachexia;
neuroimmunology;
the elderly
- From:
Fudan University Journal of Medical Sciences
2025;52(4):581-588
- CountryChina
- Language:Chinese
-
Abstract:
In elderly patients with malignant tumor,sarcopenia frequently co-occurs,which is largely attributed to the cachexia state observed in cancer patients.Although both sarcopenia and cachexia involve muscle loss,there are significant distinctions between the two conditions.Current research indicates that sarcopenia is a multifactorial condition,influenced by factors such as aging,endocrine dysfunction,motor neuron loss,cachexia,inflammation,and malnutrition.With the increasing depth of research into the correlation between sarcopenia and the nervous and immune systems,this article reviews the research progress on sarcopenia in patients with malignant tumors,with a focus on neuroimmunological aspects.It systematically analyzes the mechanisms underlying its onset and progression,as well as the influencing factors and potential intervention strategies for sarcopenia in this patient population.
