Clinical characteristics analysis of autoimmune glial fibrillary acidic protein astrocytopathy in four cases initially suspected as tuberculous meningitis
10.3969/j.issn.1672-8467.2025.04.013
- VernacularTitle:4例疑似结核性脑膜炎的自身免疫性胶质纤维酸性蛋白星形细胞病的临床特征分析
- Author:
Li-heng WANG
1
;
Xuan WANG
;
Jian-ming ZHENG
;
Qi-hui LIU
;
Ning LI
Author Information
1. 复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心 上海 200040;川北医学院附属医院感染科 南充 637000
- Publication Type:Journal Article
- Keywords:
autoimmune glial fibrillary acidic protein astrocytopathy(A-GFAP-A);
glial fibrillary acidic protein antibody;
tuberculous meningitis(TBM);
meningoencephalitis
- From:
Fudan University Journal of Medical Sciences
2025;52(4):560-565
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune glial fibrillary acidic protein astrocytopathy(A-GFAP-A)is an autoimmune-mediated central nervous system disease.Its symptoms and cerebrospinal fluid changes are often similar to those of central nervous system infectious diseases,particularly tuberculous meningitis(TBM),making it clinically challenging to differentiate between them.This article collects data on the clinical manifestations,auxiliary examinations,diagnosis and treatment of four patients with A-GFAP-A,who were suspected as TBM and subsequently admitted to Department of Infectious Diseases,Huashan Hospital,Fudan University from Jan 2020 to Sep 2023.Additionally,relevant literature is reviewed and the key points of differential diagnosis is discussed in order to enhance clinicians'understanding of A-GFAP-A.
