Research progress on the mechanism of podocyte senescence in diabetic kidney disease
10.3969/j.issn.1006-6187.2025.02.014
- VernacularTitle:糖尿病肾脏疾病足细胞衰老机制的研究进展
- Author:
Yanren WANG
1
;
Qingmiao LU
;
Yibing LU
Author Information
1. 210011 南京医科大学第二临床医学院
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease;
Cellular senescence;
Podocyte
- From:
Chinese Journal of Diabetes
2025;33(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is one of the most prevalent complications of diabetes mellitus,with progressive proteinuriaas the main clinical manifestation.Podocytes,a key structural component of the renal filtration barrier,age faster in diabetic state.Theirand morphologies gradually change,mainly in the form of multinucleation,widening of the peduncle,podocyte detachment and increased secretion of senescence-related secretory phenotypes.Various essential signaling pathways in senescent podocytes are altered in the high glucose environment,which results in mitochondrial dysfunction,increased oxidative stress and increased secretion of inflammatory factors.The removal of senescent podocyte,targeting and modulating senescence-related signaling pathways and blocking the secretionofsenescence associated secretory phenotypes may slow down the progression of DKD due to podocyte senescence.This article reviews the research progress on the mechanism of podocyte aging in DKD.
