Research advances on the mechanism of gut-brain axis metabolic imbalance in brain injury associated with fetal growth restriction
10.3760/cma.j.cn113903-20250420-00198
- VernacularTitle:肠-脑轴代谢失衡在胎儿生长受限脑损伤中机制的研究进展
- Author:
Jingyu LIU
1
;
Jing YANG
1
;
Nana HUANG
1
;
Yangyu ZHAO
1
Author Information
1. 北京大学第三医院妇产科，北京 100191
- Publication Type:Journal Article
- Keywords:
Fetal growth restriction;
Gut-brain axis;
Neurodevelopmental disorders;
Metabolite dysbiosis
- From:
Chinese Journal of Perinatal Medicine
2025;28(10):906-910
- CountryChina
- Language:Chinese
-
Abstract:
Fetal growth restriction (FGR) is a common obstetric complication associated with a significantly increased risk of perinatal neurological injury. Recent research on the gut-brain axis suggests that disruption of gut microbiota metabolic homeostasis is closely linked to the development of various fetal-origin neurological disorders. Optimizing early-life gut microbiota colonization and metabolic function may thus offer a novel therapeutic approach to mitigate brain injury and neurological sequelae. However, the precise mechanisms by which gut-brain axis and metabolite dysregulation contribute to FGR-related brain injury remain to be fully elucidated. This review focuses on the potential mechanisms through which gut microbiota metabolites regulate neurological damage in FGR, providing new insights for clinical monitoring and treatment strategies for FGR-associated brain injury.
