Traditional Chinese Medicine in Anti-gastrointestinal Tumor Treatment via Targeting Ferroptosis
10.13865/j.cnki.cjbmb.2025.01.1416
- VernacularTitle:传统中药通过靶向铁死亡抗消化道肿瘤
- Author:
Ying-Xue SHEN
1
;
Yan-Bin JIA
1
Author Information
1. 包头医学院基础医学与法医学院病原生物教研室,内蒙古包头 014040
- Publication Type:Journal Article
- Keywords:
gastrointestinal stromal tumors(GIST);
ferroptosis;
traditional Chinese medicine;
Chinese medicine monomer
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(6):853-861
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of gastrointestinal tumors is increasing year by year and it has become a world-wide health problem with high incidence and poor prognosis.Ferroptosis,a new type of cell death,is mainly caused by abnormal intracellular iron metabolism leading to excess iron,which results in high pro-duction of intracellular reactive oxygen species(ROS)and accumulation of lipid peroxides.With the gradual deepening of the study of ferroptosis,it is found that ferroptosis can sensitize gastrointestinal tumor cells to drug therapy,so as to achieve a better therapeutic effect.Therefore,ferroptosis has attrac-ted widespread attention in the field of treatment of gastrointestinal tumors in recent years.Traditional Chinese medicines have a long history and have been widely utilized in the treatment of cancer due to its low cost and fewer adverse effects.More and more studies have found that traditional Chinese medicine can induce ferroptosis in gastrointestinal tumors and thus inhibit tumor cell growth and metastasis.Here we first introduce the theory of ferroptosis,then further present traditional Chinese medicine monomers that induce ferroptosis in gastrointestinal tumor cells through modulating iron metabolism,inhibiting fer-roptosis related antioxidant system and regulating nuclear factor erythroid 2-related factor 2(NRF2),thereby inhibiting gastrointestinal tumorigenesis and progression.Moreover,we expound the research of anti-gastrointestinal tumor using traditional Chinese medicine and traditional Chinese medicine monomer combined with chemotherapy drugs to provide a new way of thinking for the treatment of digestive tract tumors.
