The Impact of Serum Vitamin B12 on The Prognosis of Newly Diagnosed Multiple Myeloma Patients
10.13865/j.cnki.cjbmb.2025.03.1026
- VernacularTitle:血清维生素B12对新诊断多发性骨髓瘤患者预后的影响
- Author:
Chuan HE
1
;
Xiao-Hui ZHANG
;
Ping CHEN
;
Wen-Zhuo ZHUANG
;
Bing-Zong LI
Author Information
1. 苏州大学附属第二医院血液科,江苏苏州 215000
- Publication Type:Journal Article
- Keywords:
multiple myeloma(MM);
vitamin B12(Vit B12);
extramedullary infiltration;
T lympho-cyte subsets;
prognosis
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(6):807-814
- CountryChina
- Language:Chinese
-
Abstract:
A subset of patients with multiple myeloma(MM)present with reduced serum vitamin B12 levels at initial diagnosis;however,its clinical significance and underlying mechanisms remain unclear.Vitamin B12 plays a crucial role in hematopoiesis and immune regulation.This study aims to elucidate its association with extramedullary diseases,immune function,and prognosis in MM patients.A retrospec-tive analysis was conducted of 92 newly diagnosed MM patients,who received treatment at the Second Af-filiated Hospital of Soochow University between January 2020 and December 2023.Patients were classi-fied into a low vitamin B12 group(n=37)and a normal vitamin B12 group(n=55)based on their ser-um vitamin B12 levels.The findings revealed that the incidence of extramedullary infiltration was signifi-cantly higher in the low vitamin B12 group than in the normal group(26.5％vs.17.0％,P=0.031).Survival analysis demonstrated that patients with low vitamin B12 levels had significantly shorter overall survival(OS)and progression-free survival(PFS)(OS:P=0.0123;PFS:P=0.0136).Additionally,these patients showed a decreasing trend in peripheral blood total T cell,CD4+T cell,and CD8+T cell counts,with serum vitamin B12 levels showing a significant positive correlation with the total T cell count(R=0.2717,P=0.0135)and CD4+T cell count(R=0.2175,P=0.0497).In conclusion,reduced serum vitamin B12 levels at initial diagnosis are significantly associated with poor prognosis in MM pa-tients and may serve as a potential prognostic biomarker.Furthermore,vitamin B12 deficiency may con-tribute to immune dysfunction,particularly impaired T cell immunity,and a higher incidence of extr-amedullary diseases.
