Structural basis of neurovascular coupling and its application in neonatal brain function assessment
10.3760/cma.j.cn113903-20250423-00205
- VernacularTitle:神经血管耦合的结构基础及其在新生儿脑功能检查中的应用
- Author:
Ling ZHAO
1
;
Laishuan WANG
1
Author Information
1. 复旦大学附属儿科医院新生儿诊疗中心、国家儿童医学中心，国家卫生健康委员会新生儿疾病重点实验室，上海 201102
- Publication Type:Journal Article
- Keywords:
Neurovascular coupling;
Infant, newborn;
Brain function;
Neurovascular unit;
Hemodynamics
- From:
Chinese Journal of Perinatal Medicine
2025;28(12):1082-1088
- CountryChina
- Language:Chinese
-
Abstract:
Neurovascular coupling (NVC) is a fundamental mechanism that maintains the dynamic balance between cerebral metabolic demands and stable blood supply, playing a crucial role in supporting brain development and basic functions. Impaired NVC may lead to local cerebral ischemia and hypoxia, consequently affecting neural signal transmission and indirectly reflecting alterations in brain function. In recent years, various non-invasive imaging technologies based on NVC have been applied for brain function assessment. However, the application of these techniques in neonates remains limited. The neonatal period represents a critical phase for brain development and maturation, during which the brain is highly vulnerable to various injurious factors. Therefore, there is an urgent need for non-invasive, high-resolution, and highly sensitive brain function assessment methods to facilitate timely clinical diagnosis, treatment, and nursing strategy formulation. This review aims to summarize the structural basis of NVC and its current applications in neonatal brain function evaluation.
