Meta Analysis of the Diagnostic Value of Serum Mycoplasma Pneumoniae Specific Antibody Detection for Mycoplasma Pneumoniae Pneumonia in Children
10.3969/j.issn.1671-7414.2025.04.034
- VernacularTitle:血清肺炎支原体特异性抗体检测对儿童肺炎支原体肺炎诊断价值的Meta分析
- Author:
Xueling ZHANG
1
;
Qingqin YIN
;
Xirong WU
;
Xiaohui LIU
;
Meiru YAN
;
Yali LIU
;
Baoping XU
Author Information
1. 国家儿童医学中心,国家呼吸系统疾病临床医学研究中心,首都医科大学附属北京儿童医院呼吸中心,中国医学科学院儿童危重感染诊治创新单元,北京 100045
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae pneamonia;
Mycoplasma pneumoniae antibody;
meta-analysis
- From:
Journal of Modern Laboratory Medicine
2025;40(4):188-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of positive serum specific antibodies to Mycoplasma pneumoniae(MP)in children with Mycoplasma pneumoniae pneumonia(MPP).Methods PubMed,Cochrane Library,Embase,Sinomed,CNKI,Wanfang and VIP databases were searched for studies on the detection of MPP based on antibodies from the establishment of the database to March 31,2023.After literature screening and data extraction,STATA 16.0 software was used for Meta-analysis.Results A total of 9 literatures and 2 148 clinical samples were included.The combined sensitivities[M(95%CI)]of particle agglutination assay(PA)and enzyme-linked immunosorbent assay(ELISA)were 50%(31～69)and 88%(85～90),and the combined specificities[M(95%CI)]were 88%(76～95)and 88%(62～97).The combined diagnostic odds ratio(DOR)[M(95%CI)]were 5.61(3.30～9.53)and 43.82(12.78～150.19),and the summary receiver operating characteristic curve(SROC)area under the curve(AUC)were 0.80 and 0.88,respectively.Conclusion Serum MP specific antibody detection can be used for diagnosis and screening of children MPP,but needs to be combined with clinical symptoms improve the accuracy of the diagnosis.
