Advances in the application of single-cell sequencing in obstetrics
10.3760/cma.j.cn113903-20241015-00681
- VernacularTitle:单细胞测序在产科的应用研究进展
- Author:
Mingming XU
1
;
Yaping WANG
1
;
Tianshuang LI
1
;
Youdi XU
1
Author Information
1. 南京医科大学附属南京医院产科，南京 210001
- Publication Type:Journal Article
- Keywords:
Single-cell sequencing;
Obstetrics;
Placenta;
Maternal-fetal immunity;
Multiomics
- From:
Chinese Journal of Perinatal Medicine
2025;28(12):1159-1162
- CountryChina
- Language:Chinese
-
Abstract:
Single-cell sequencing technology is illuminating the complex molecular mechanisms of placental development, maternal-fetal immune regulation, and pregnancy-related disorders. This review outlines the fundamental principles of single-cell sequencing, and explores its specific applications in obstetric research, with a focus on its technical advantages in revealing the pathophysiology of conditions such as preeclampsia, gestational diabetes, and preterm birth. The article discusses existing technical limitations, ethical considerations, and concludes with a perspective on future directions, including advances in technology, the growing promise for clinical application, and the potential of multi-omics integration in obstetrics research.
