Analysis of Clinical Characteristics and Drug Sensitivity Spectrum of Pathogenic Bacteria in 1 091 Prepubertal Children with Vulvovaginitis in Xi'an Area from 2019 to 2023
10.3969/j.issn.1671-7414.2025.04.032
- VernacularTitle:2019～2023年西安地区1 019例青春期前儿童外阴阴道炎临床特征及病原菌学与药敏谱分析
- Author:
Wei WANG
1
;
Zengguo WANG
;
Kai JIA
;
Huan QIANG
;
Lin WANG
Author Information
1. 西安市儿童医院检验科,西安 710003
- Publication Type:Journal Article
- Keywords:
prepubertal children;
vulvovaginitis;
pathogenic bacteria;
resistance;
Xi'an area
- From:
Journal of Modern Laboratory Medicine
2025;40(4):179-182,207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and pathogen resistance of vulvovaginitis among prepubertal children in Xi'an area,so as to provide valuable insights for clinical diagnosis and treatment.Methods A total of 1 019 children(aged<10 years)diagnosed with prepubertal vulvovaginitis in Xi'an Children Hospital from January 2019 to December 2023 were selected as the research objects.The clinical characteristics and drug resistance of pathogenic bacteria were analyzed.Results The number of children with prepubertal vulvovaginitis increased significantly after the end of the COVID-19 pandemic.The positive detection rate in 2023 increased by 13.18%compared to that in 2019,with a significant rise in bacterial vulvitis compared to fungal infection.Common clinical manifestations among diagnosed children included increased secretion and vulvar pruritus.As age increased,the detection rate of pathogenic bacteria also rose,reaching a high positive proportion of 37.29%among children aged 8～<10 years old.Pathogenic bacteria isolated in the laboratory mainly consisted of Haemophilus influenzae(30.72%,313/1 019),Candida albicans(28.46%,290/1 019)and Streptococcus pyogenes(20.61%,210/1 019).Notably,the detection rates of these pathogens exhibited significant variations among children of different age groups(χ2=279.26,382.97,83.48,all P<0.05).Among them,vulvitis in children under 8 years old were mainly caused by respiratory bacterial infections,while those aged 8～<10 tended to be consistent with adults and were mainly caused by candidal vulvitis.The drug sensitivity test results indicated that Haemophilus influenzae exhibited high resistance rates to ampicillin and cefuroxime but good sensitivity to third-generation cephalosporins.Candida albicans showed good sensitivity to common antifungal drugs.Streptococcus pyogenes displayed high sensitivity to penicillin,ampicillin and ceftriaxone but strong resistance(>90%)against erythromycin and clindamycin.Conclusion The positive rate of vulvitis has been increasing among prepubertal children in Xi'an recent years.Pathogenic bacteria are concentrated and sensitive towards common antibiotics.Early submission of clinical samples,rational use of medications and reinforcement on healthy habits guidance are recommended for timely intervention in the development of the disease.
