Research status of targeting cancer-associated fibroblasts to overcome tumor drug resistance
10.13699/j.cnki.1001-6821.2024.24.026
- VernacularTitle:靶向肿瘤相关成纤维细胞逆转肿瘤耐药的研究现状
- Author:
Jia-ni ZHONG
1
;
Zhi LI
;
Jia CHEN
;
Ze-ting YUAN
;
Pei-hao YIN
Author Information
1. 成都中医药大学医学与生命科学学院,四川成都 610075
- Publication Type:Journal Article
- Keywords:
tumor;
cancer-associated fibroblasts;
tumor microenvironment;
targeted therapy;
drug resistance
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(24):3648-3652
- CountryChina
- Language:Chinese
-
Abstract:
The tumor microenvironment(TME)exerts a profound impact on tumor cells,and cancer-associated fibroblasts(CAFs),as one of the most critical and abundant components of the TME,play a key role in tumor growth and development,stroma formation,as well as drug resistance and recurrence.CAFs actively partake in the development of tumor drug resistance via mechanisms such as secretion of soluble factors,exosome release,induction of epithelial-to-mesenchymal transition,regulation of vascular reconstruction,initiation of epigenetic modifications,facilitation of metabolic reprogramming,and sustenance of tumor stem cells.This paper reviews the origin of CAFs,their association with drug resistance,strategies against CAFs,and also discusses the future prospects and challenges of targeting CAFs,aiming to provide the basis for the therapeutic strategy of reversing tumor drug resistance by targeting CAFs.
