Analysis Drug Resistance of 726 Strains of Mycobacterium Tuberculosis in Clinical Patients in Shaanxi Area form 2019 to 2023
10.3969/j.issn.1671-7414.2025.04.030
- VernacularTitle:2019～2023年陕西地区临床患者726株结核分枝杆菌耐药检测情况分析
- Author:
Yajing WU
1
;
Rui WANG
;
Yan LI
;
Jian YANG
;
Panting WANG
;
Meng ZHANG
Author Information
1. 西安市第九医院,西安 710054
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
drug resistance;
Shaanxi area
- From:
Journal of Modern Laboratory Medicine
2025;40(4):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the drug resistance of Mycobacterium tuberculosis(MT)in Shaanxi Province in the past five years.Methods A total of 744 patients with culture-positive sputum specimens at the former Shaanxi Provincial Institute for Tuberculosis Control and Prevention from January 2019 to December 2023 were selected as the study subjects,and the results of their strain identification and drug susceptibility tests were collected to analyze the resistance to six antituberculosis drugs.Results The overall resistance rate of the MT complex of 726 strains was 33.33%(242/726).The rates of mono-resistance,multi-resistance,multi-drug resistance and extensive resistance were 12.95%(94/726),7.44%(54/726),12.95%(94/726)and 0.41%(3/726).The resistance rate was 31.73%(204/643)in primaries and 45.78%(38/83)in retreatment patients,and the difference between the resistance rates of primaries and retreatment patients was statistically significant(χ2=6.536,P=0.011).The resistance rates of the 6 antituberculosis drugs,in descending order,were as follows:streptomycin(SM)22.87%(166/726),isoniazid(INH)22.73%(165/726),rifampicin(RFP)15.15%(110/726),ofloxacin(OFX)9.09%(66/726),ethambutol(EMB)7.30%(53/726),kanamycin(KM)2.89%(21/726).The resistance rates for each year from 2019～2023 were 39.61%(61/154),33.33%(44/132),34.47%(81/235),24.54%(40/163)and 38.10%(16/42),respectively,and the difference in resistance rates between years was not statistically significant(χ2=8.967,P=0.062).Conclusion The burden of drug-resistant tuberculosis remains heavy in Shaanxi,and the situation of multidrug-resistant tuberculosis,in particular,is more serious,and control measures need to be strengthened and improved to reduce the incidence and spread of drug-resistant tuberculosis.
