Clinical trial of levocarnitine combined with mecobalamine in the treatment of patients with uremic peripheral neuropathy
10.13699/j.cnki.1001-6821.2024.24.008
- VernacularTitle:左卡尼汀联合甲钴胺治疗尿毒症周围神经病变患者的临床研究
- Author:
Jia-kui WAN
1
;
Ling-yun ZHANG
;
Hong WANG
;
Jin-yu LI
Author Information
1. 黄山市人民医院血液净化科,安徽黄山 245000
- Publication Type:Journal Article
- Keywords:
levocarnitine injection;
mecobalamine injection;
uremic peripheral neuropathy;
clinical curative effect;
nerve conduction velocity;
oxidative stress response
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(24):3558-3562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effect of levocarnitine injection combined with mecobalamine injection and hemodialysis in uremic peripheral neuropathy.Methods The patients with uremic peripheral neuropathy were divided into treatment group and control group according to cohort method.The patients in the control group was given mecobalamine injection,0.5 g each time,after each dialysis,3 times a week,intravenous drip.On the basis of the treatment of the control group,the treatment group was given levocarnitine injection,1 g each time,after each dialysis,3 times a week,intravenous drip.Both groups were treated for 12 weeks.Results There were 35 cases in control group and 45 cases in treatment group.After treatment,total response rates of treatment group and control group were 93.33％(42 cases/45 cases)and 77.14％(27 cases/35 cases),the difference was statistically significant(P＜0.05).After treatment,sensory nerve conduction velocity(SCV)of common peroneal nerve in treatment group and control group were(41.73±4.05)and(38.67±3.73)m·s-1;MCV of common peroneal nerve were(46.62±4.41)and(43.51±4.29)m·s-1;levels of serum advanced oxidized protein product were(81.75±14.36)and(109.43±18.57)μmol·L-1;levels of glutathione peroxidase were(73.39±6.05)and(61.83±5.72)U·L-1;levels of superoxide dimutase were(90.68±11.28)and(79.95±9.03)U·L-1,differences were statistically significant(all P＜0.05).The adverse drug reactions in treatment group were mainly on rash,loss of appetite and dizziness,while which in control group were mainly on loss of appetite,diarrhea and vomiting.There were no significant difference in total incidence of adverse drug reactions between treatment group and control group[11.11％(5 cases/45 cases)vs 8.57％(3 cases/35 cases)].Conclusion Curative effect of levocarnitine injection combined with mecobalamine injection and hemedialysis is significant in patients with uremic peripheral neuropathy,which can relieve clinical symptoms and promote the recovery of nerve conduction velocity.
