Research status of programmed cell death in pathogenesis of acute pancreatitis

VernacularTitle:细胞程序性死亡在急性胰腺炎发病机制中的研究现状
Author: Yu ZHANG ¹ ; Min BAI ; Zhan-dong WANG ; Yuan LIAN ; Qiong WANG ; Bing SONG ; Chao GUO ; Yong-feng WANG ; Yan-ying ZHANG
Author Information

1. 甘肃中医药大学第一临床医学院,甘肃兰州 730000
Publication Type:Journal Article
Keywords: acute pancreatitis; procedural cell death; acinar cell
From: The Chinese Journal of Clinical Pharmacology 2024;40(23):3492-3496
CountryChina
Language:Chinese
Abstract: Acute pancreatitis(AP)is one of the most common clinically critical diseases,and pancreatic acinar cell death is a central event in the pathological course of AP and a key factor in determining the degree of local or systemic inflammatory damage as well as overall pancreatitis.Programmed cell death is an active and orderly way of death that is regulated by program and widely exists in the development of organisms.A variety of programmed death modes are widely involved in the damage of AP acinar cells,mainly including autophagy,pyrodeath and iron death,etc.This study systematically reviews the mechanism of programmed death in AP acinar cells.The aim is to provide a new understanding of the specific pathogenesis of AP,and to provide new ideas and strategies for the treatment of the disease.