Research progress on p120-catenin in vascular development and endothelial barrier function
10.3969/j.issn.1672-8467.2025.04.015
- VernacularTitle:p120连环蛋白在血管发育和内皮屏障功能中的研究进展
- Author:
Xi XUE
1
;
Yi-wen MAO
;
Ming-jie WANG
Author Information
1. 复旦大学临床医学院 上海 200032
- Publication Type:Journal Article
- Keywords:
p120-catenin(p120ctn);
vascular endothelial cadherin(VE-cadherin);
neovascularization;
endothelial barrier
- From:
Fudan University Journal of Medical Sciences
2025;52(4):572-580
- CountryChina
- Language:Chinese
-
Abstract:
p120-catenin(p120ctn)is one of the crucial members of armadillo family,which is well known as a core stabilizing factor for vascular endothelial cadherin(VE-cadherin).Throughout the entire process of vascular development,p120ctn plays multiple roles.From neovascularization to endothelial barrier,the presence of p120ctn is indispensable.It participates in regulating the normal development of vertebrate embryo vasculature and promoting endothelial cell proliferation.Additionally,p120ctn contributes to the maintenance and remodeling of adherens junctions and can modulate adhesion strength by altering cell morphology.This review summarized the latest research progress on p120ctn from neovascular development and endothelial barrier function.
