Ethical risks and possible management strategies in newborn screening
10.3760/cma.j.cn113903-20241016-00688
- VernacularTitle:新生儿筛查的伦理风险及化解之道
- Author:
Qiman LIU
1
;
Wenpei TANG
1
Author Information
1. 北京大学医学人文学院，北京 100191
- Publication Type:Journal Article
- Keywords:
Newborn screening;
Tandem mass spectrometry;
High-throughput sequencing;
Ethical risks;
Common good
- From:
Chinese Journal of Perinatal Medicine
2025;28(7):619-623
- CountryChina
- Language:Chinese
-
Abstract:
This study analyzes ethical and social challenges arising from advanced technologies, specifically tandem mass spectrometry and high-throughput sequencing in newborn screening. Key issues include disease selection criteria, false-negative/false-positive results, and genetic stigmatization. Framing newborn screening as acommon good for societal wellbeing, we advocate for a neonate-centered ethical framework. This necessitates enhanced dynamic ethical review and informed consent processes; establishment of a newborn screening program with integrated clinical interpretation support, adverse-outcome monitoring and compensation mechanisms; and strengthened legal safeguards for privacy and confidentiality. These integrated approaches are essential to minimize ethical risks.
