Clinical value of endothelial cell-specific molecule-1 in cerebrospinal fluid on assessment of severity and outcome in patients with moderate to severe traumatic brain injury
10.3969/j.issn.1672-8467.2025.04.005
- VernacularTitle:脑脊液内皮细胞特异性分子-1在评估中-重度颅脑创伤患者伤情及预后中的临床价值
- Author:
De-wen RU
1
;
Wen-na YAN
1
;
Meng LIU
1
;
Yu-qi WANG
1
;
Er-song WANG
1
;
Yu-feng YAN
1
Author Information
1. 复旦大学附属金山医院神经外科 上海 201508
- Publication Type:Journal Article
- Keywords:
traumatic brain injury(TBI);
cerebrospinal fluid;
endothelial cell-specific molecule-1(ESM-1);
intracranial pressure(ICP);
clinical value
- From:
Fudan University Journal of Medical Sciences
2025;52(4):506-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in the concentration of endothelial cell-specific molecule-1(ESM-1)in cerebrospinal fluid during the acute phase of patients with moderate to severe traumatic brain injury(TBI)and its relationship with injury severity and outcomes.Methods Eighty-four patients with moderate to severe TBI who underwent ventriculostomy for intracranial pressure(ICP)monitoring at Department of Neurosurgery,Jinshan Hospital,Fudan University from Jan 2020 to Dec 2023 were selected as the study subjects,and their clinical data were collected.Based on the Glasgow Coma Scale(GCS)upon admission,TBI patients were divided into moderate TBI group(GCS 9-12,n=48)and severe TBI group(GCS 3-8,n=36).According to the Glasgow Outcome Scale(GOS)at three months post-injury,the moderate to severe TBI patients were categorized into poor outcome group(GOS 1-3)and good outcome group(GOS 4-5).Patients were also classified based on ICP monitoring values into a normal ICP group(ICP≤15 mmHg),a mildly elevated ICP group(15 mmHg
