Correlation between Polymorphism at rs35678,rs2289274 Loci of ATP2B2 Gene and Benign Paroxysmal Positional Vertigo
10.3969/j.issn.1671-7414.2025.04.003
- VernacularTitle:ATP2B2基因rs35678,rs2289274位点多态性与良性阵发性位置性眩晕的相关性研究
- Author:
Jiang WU
1
;
Haili GUO
Author Information
1. 西安工会医院耳鼻喉科,西安 710199;陕西中医药大学第二附属医院耳鼻咽喉科,陕西 咸阳 712000
- Publication Type:Journal Article
- Keywords:
benign paroxysmal positional vertigo;
single nucleotide polymorphism;
ATPase plasma membrane Ca2+ transporting 2
- From:
Journal of Modern Laboratory Medicine
2025;40(4):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between polymorphisms at the rs35678,rs2289274 loci of the ATPase plasma membrane Ca2+transporting 2(ATP2B2)gene and benign paroxysmal positional vertigo(BPPV).Methods 186 BPPV patients admitted to Xi'an Trade Union Hospital from January 2022 to January 2024 were selected as the BPPV group,and another 100 healthy individuals who underwent physical examination during the same period were selected as the control group.Polymerase chain reaction(PCR)was used to detect polymorphisms at the rs35678 and rs2289274 loci of the ATP2B2 gene.Allele and genotype frequencies were compared between the two groups.Unconditional Logistic regression was used to analyze the correlation with BPPV susceptibility under three genetic models(co-dominant,dominant and recessive)for the rs35678 and the rs2289274 loci.Results The distribution of genotypes at the rs35678 and rs2289274 loci of the ATP2B2 gene in the control group,and the BPPV group were all in accordance with the Hardy-Weinberg law of equilibrium(χ2=0.003～0.050,all P>0.05),and had a representativeness of the groups.Compared with the control group,the allele T frequency(56.45%vs 41.00%)and genotype TT frequency(31.87%vs 16.81%)were significantly higher in the BPPV group at the rs35678 locus,and the allele A frequency(54.30%vs 42.00%)and genotype AA frequency(29.48%vs 17.64%)at the rs2289274 locus,and the differences were statistically significant(χ2=3.936～12.290,all P<0.05).Under the codominant model(CC vs TT)for the rs35678 locus,carriers of TT genotype had an increased risk of disease compared to carriers of CC genotype(OR=1.851,95%CI:1.059～2.936);Under both the dominant model(CT+TT vs CC)and recessive model(CT+CC vs TT),the rs35678 polymorphism showed a statistically significant association with BPPV(OR=1.716,95%CI:1.074～2.936;OR=0.759,95%CI:0.517～0.837),and the differences were statistically significant(all P<0.05),reqectively.Under the codominant model(GG vs AA)for the rs2289274 locus,carriers of the AA genotype had a higher risk of disease compared to carriers of the GG genotype(OR=1.627,95%CI:1.191～2.973);in the dontinant model(AG+AA vs GG)the polymorphisms at the rs2289274 locus showed a significant association with BPPV(OR=1.941,95%CI:1.191～3.673),the differences were statistically significant(P<0.05).Conclusion The TT genotype at the rs35678 locus and the AA genotype at the rs2289274 locus of the ATP2B2 gene increase the risk of developing BPPV.
