Impact of Hemoglobin Concentration on 5-year Cardiac Mortality in Patients With Hypertrophic Obstructive Cardiomyopathy
10.3969/j.issn.1000-3614.2025.07.008
- VernacularTitle:血红蛋白浓度对梗阻性肥厚型心肌病患者5年心原性死亡风险的影响
- Author:
Jun GAO
1
;
Pengqiang LI
;
Chao WU
;
Yitian ZHENG
;
Jie YANG
;
Jingjia WANG
;
Wenyao WANG
;
Kuo ZHANG
Author Information
1. 北京大学第三医院 心内科 血管医学研究所 血管稳态与重构全国重点实验室(北京大学),北京 100191
- Publication Type:Journal Article
- Keywords:
hypertrophic obstructive cardiomyopathy;
hemoglobin;
cardiac death
- From:
Chinese Circulation Journal
2025;40(7):689-694
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To evaluate the impact of hemoglobin concentration on 5-year cardiovascular mortality in patients with hypertrophic obstructive cardiomyopathy(HOCM).Methods:This study retrospectively analyzed 325 non-surgically treated HOCM patients hospitalized at Fuwai Hospital from October 2009 to December 2014.Baseline information was compared between patients with or without cardiac death.The impact of hemoglobin concentration on 5-year cardiovascular mortality in HOCM patients was analyzed.Results:The median follow-up time was(43.55±19.70)months.During the follow-up period,a total of 29 patients(8.9%)experienced cardiac death.Univariate Cox regression analysis demonstrated that hemoglobin concentration was significantly associated with 5-year cardiac mortality in HOCM patients(P<0.001).After adjusting for potential cardiovascular risk factors in multivariate Cox regression analysis,hemoglobin concentration(P=0.011)remained negatively associated with 5-year cardiac mortality in HOCM patient.HOCM patients with decreased hemoglobin level faced a 3.118-fold increase in 5-year cardiac mortality(HR=4.118,95%CI:1.114-14.822,P=0.030).Kaplan-Meier survival analysis showed that HOCM patients with decreased hemoglobin levels had a significantly higher risk of 5-year cardiac mortality(log-rank test,χ2=24.38,P<0.001).Conclusions:Lower hemoglobin concentration is an independent risk factor for 5-year cardiac mortality in patients with HOCM.Compared to patients with normal hemoglobin levels,HOCM patients with decreased hemoglobin level face a 3-fold increase in 5-year cardiac mortality.
