Reflection on low molecular weight heparin in obstetric practice
10.3760/cma.j.cn113903-20240319-00207
- VernacularTitle:低分子量肝素在产科的应用与思考
- Author:
Yike YANG
1
;
Hongbo QI
Author Information
1. 北京大学第三医院妇产科，北京 100191
- Publication Type:Journal Article
- Keywords:
Heparin, low-molecular-weight;
Peripartum period;
Molecular mechanisms of pharmacological action;
Drug-related side effects and adverse reactions;
Drug do
- From:
Chinese Journal of Perinatal Medicine
2025;28(6):466-472
- CountryChina
- Language:Chinese
-
Abstract:
Low molecular weight heparin (LMWH) is an anticoagulant derived from the chemical cleavage of standard heparin, which possesses similar anticoagulant effects. LMWH has high bioavailability, a long half-life, does not cross the placentas, and is considered to be a safe medication during pregnancy. Consequently, LMWH is widely used in the prevention and treatment of various obstetric conditions. However, the clinical application of LMWH still encounters the problem of overconsumption and non-standardized usage. Based on existing evidence, this article summarizes the molecular mechanism of LMWH, its indications in obstetrics, side effects, and dosage selection in particular situations, aiming to provide insights into achieving a balance of benefits and potential risks for applying LMWH in obstetrics.
