Relationship between Serum IL-32β,LncRNA-TCL6 Expression Levels and Clinical Adverse Pregnancy Outcomes in Pregnant Women with Severe Preeclampsia
10.3969/j.issn.1671-7414.2025.04.019
- VernacularTitle:重度子痫前期孕妇血清IL-32β,lncRNA-TCL6表达水平与临床不良妊娠结局的关系研究
- Author:
Haixia LIU
1
;
Chunyan LÜ
1
;
Dan LIU
1
Author Information
1. 四川锦欣妇女儿童医院产科,成都 610066
- Publication Type:Journal Article
- Keywords:
severe preeclampsia;
interleukin-32β;
long chain non-coding ribonucleic acid T-cell leukemia/lymphoma 6;
pregnancy outcome
- From:
Journal of Modern Laboratory Medicine
2025;40(4):111-115,203
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum interleukin(IL)-32β and long non-coding RNA-T cell leukemia/lymphoma 6(lncRNA-TCL6)in women with severe preeclampsia(sPE)and its relationship with adverse pregnancy outcomes.Methods A total of 316 women with sPE(sPE group)and 323 healthy pregnant women(control group)admitted to Sichuan Jinxin Women and Children's Hospital from November,2020 to June,2023 were enrolled.Serum IL-32β and lncRNA-TCL6 were detected,and pregnancy outcomes were followed up.Multivariate Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in women with sPE.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of IL-32β and lncRNA-TCL6 in predicting the pregnancy outcomes of sPE.Results The serum IL-32β level(4.13±1.46 pg/ml)and lncRNA-TCL6 expression(1.36±0.30)in the sPE group were higher than those in the control group(2.35±0.77 pg/ml,0.89±0.21),and the differences were statistically significant(t=19.335,22.983,all P<0.05).The level of serum IL-32β(4.65±0.39 pg/ml)and the expression of lncRNA-TCL6(1.42±0.19)in the poor outcome group were higher than those in the good outcome group(3.98±0.37pg/ml,1.34±0.11),and the differences were statistically significant(t=13.207,4.480,all P<0.05).Early onset preeclampsia,high levels of IL-32β and high expression of lncRNA-TCL6 were risk factors for adverse pregnancy outcomes in sPE patients(Wald χ2=6.138,1.921,1.702,all P<0.05).The AUC of IL-32 β,lncRNA-TCL6,and their combined prediction of sPE pregnancy outcomes were 0.815,0.825 and 0.958,respectively.The combined prediction of IL-32β and lncRNA-TCL6 was higher than the individual prediction,and the differences were statistically significant(Z=4.502,4.017,all P<0.05).Conclusion The serum levels of IL-32β and lncRNA-TCL6 are increased in patients with sPE,which are related to the adverse pregnancy outcome.Combined IL-32β and lncRNA-TCL6 have a high value in predicting the pregnancy outcome of patients with sPE.
