The level and significance of miR-193b-3p in patients with aneurysmal subarachnoid hemorrhage after hyperbaric oxygen treatment
10.3760/cma.j.cn311847-20210315-00086
- VernacularTitle:动脉瘤性蛛网膜下腔出血患者高压氧治疗后血清miR-193b-3p水平及其意义
- Author:
Chunyan ZHAO
1
;
Shumin TU
1
;
Bing XUE
1
;
Changyue LUO
1
;
Xiaodan ZHOU
1
Author Information
1. 商丘市第一人民医院急诊科，商丘 476000
- Publication Type:Journal Article
- Keywords:
Aneurysmal subarachnoid hemorrhage;
miR-193b-3p;
Hyperbaric oxygen
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(1):102-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in the level of microRNA-193b-3p（miR-193b-3p）in patients with aneurysmal subarachnoid hemorrhage（aSAH）after hyperbaric oxygen（HBO）treatment and to explore its significance.Methods:A total of 176 patients with aSAH admitted to the Emergency Department of the First People’s Hospital of Shangqiu from January 2019 to September 2020 were selected as the research subjects. They were divided into sound prognosis group（ n=128）and poor prognosis group（ n=48）according to scores of the modified Rankin Scale（mRS）90 days after treatment. The relative expression levels of miR-193b-3p were detected by real-time quantitative PCR（RT-qPCR）. The prognostic risk factors of aSAH patients were analyzed by logistic regression. The value of miR-193b-3p in judging the prognosis of aSAH patients was evaluated by receiver operating characteristic（ROC）curve. The dose-response relationship between miR-193b-3p and prognosis in aSAH patients was analyzed by the logistic regression using restricted cubic splines. Results:The relative expression levels of miR-193b-3p in the sound prognosis group before and after treatment were higher than those in the poor prognosis group at the same time points（ P<0.05），and the relative expression levels of miR-193b-3p in both groups were decreased after treatment（ P<0.05）. The area under the ROC curve（AUC），sensitivity，and specificity of post-treatment miR-193b-3p in judging the prognosis of aSAH patients were 0.818，68.75%，and 85.94%，respectively. Hunt-Hess Ⅲ-Ⅳ，cerebral vasospasm（CVS），Glasgow Coma scale（GCS）rating，and high C-reactive protein（CRP）level were independent risk factors for aSAH prognosis（ P<0.05）；the relatively high expression level of post-treatment miR-193b-3p was an independent protective factor for aSAH prognosis（ P<0.05）. Post-treatment miR-193b-3p had a non-linear relationship with the prognosis of aSAH（ P<0.05）. Conclusion:After HBO treatment，the relative expression level of miR-193b-3p in aSAH patients was decreased，which is related to the poor prognosis of aSAH.
