Naming and diagnosis of cystic fibrosis: from the legend of "salty kiss" to genetic discovery
10.3760/cma.j.cn113903-20240902-00601
- VernacularTitle:从咸吻传说到基因发现：囊性纤维化的命名与诊断
- Author:
Cong WANG
1
;
Wenpei TANG
1
Author Information
1. 北京大学医学人文学院，北京 100191
- Publication Type:Journal Article
- Keywords:
Cystic fibrosis;
CFTR gene;
Dorothy Anderson;
Sweat test
- From:
Chinese Journal of Perinatal Medicine
2025;28(3):262-265
- CountryChina
- Language:Chinese
-
Abstract:
The history of cystic fibrosis (CF) can be traced back to the Middle Ages when a salty taste was recognized as an early symptom. In the 1930s, Dorothy Anderson gradually revealed the characteristics and mechanisms of CF through clinical and pathological studies. In 1953, the sweat test became an important tool for diagnosing CF. In 1989, scientists identified the CFTR genes and their association with CF, leading to significant advancement in genetic research and treatment of CF. By tracing the history and research progress of CF, we witness the transition from ancient legends to modern scientific exploration. This journey not only demonstrates the advancement of medical technology but also reflects the continuous deepening of human understanding of diseases, highlighting the immense potential of scientific research in improving human health.
