Research progress on NLRP3 inflammasome in microglia in ischemic stroke
10.3969/j.issn.1000-484X.2025.06.040
- VernacularTitle:小胶质细胞NLRP3炎症小体在缺血性脑卒中中的研究进展
- Author:
Xin GAO
1
;
Gang SU
;
Miao CHAI
;
Wei CHEN
;
Minghui SHEN
;
Yang AN
;
Zhenzhen HU
;
Zhenchang ZHANG
Author Information
1. 兰州大学第二医院神经内科,兰州 730030
- Publication Type:Journal Article
- Keywords:
Ischemic stroke;
NLRP3 inflammasome;
Microglia;
Polarization;
Pyroptosis;
Autophagy
- From:
Chinese Journal of Immunology
2025;41(6):1504-1511
- CountryChina
- Language:Chinese
-
Abstract:
After ischemic stroke,intracranial cells experience stress due to ischemic and hypoxic injury,leading to a series of aseptic immune response processes.The oxidative stress process in microglias triggers the activation of the NLRP3 inflammasome,which promotes the release of inflammatory factors such as IL-1β and IL-18,contributing to the inflammatory reaction caused by isch-emic stroke.In addition,NLRP3 inflammasome is involved in the polarization,pyroptosis and autophagy of microglias,regulating the prognosis of ischemic stroke.This review summarizes the specific mechanisms of NLRP3 inflammasome in regulating microglial status and its involvement in ischemia-reperfusion injury.It also discusses the associated treatment strategies,identifies the current research focus and blanks,and provides some guidance and ideas for future research.
