Central nervous system infection caused by Bacillus cereus in a neonate
10.3760/cma.j.cn113903-20240925-00643
- VernacularTitle:新生儿蜡样芽孢杆菌中枢神经系统感染1例
- Author:
Rong YU
1
;
Jing WANG
1
;
Zhihui RONG
1
Author Information
1. 华中科技大学同济医学院附属同济医院新生儿科，武汉 430030
- Publication Type:Journal Article
- Keywords:
Bacillus cereus;
Central nervous system infection;
Premature neonate;
Breast milk
- From:
Chinese Journal of Perinatal Medicine
2025;28(3):253-257
- CountryChina
- Language:Chinese
-
Abstract:
This paper reported a central nervous system infection caused by Bacillus cereus in a neonate. The patient was born prematurely at 33 weeks of gestation and 1 day. He was transferred to Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, on October 5, 2022 (day 38 of life), due to recurrent fever. Multiple cerebrospinal fluid and head MRI examinations indicated purulent meningitis with abscesses formation, though repeated blood and cerebrospinal fluid cultures were negative. At 38 days of life, metagenomic next-generation sequencing of the cerebrospinal fluid pathogens revealed the presence of the Bacillus cereus group. The patient was treated with vancomycin followed by sequential linezolid for anti-infective therapy, leading to significant improvement. The patient was discharged on day 67 of life. Follow-up at 98 days of life showed improved head MRI findings and symptom resolution. At 2 years of age, telephone follow-up indicated normal growth and development with no abnormalities.
