Analysis of the curative effect of radioactive 131I therapy assisted by hyperbaric oxygen on elderly patients with hyperthyroidism
10.3760/cma.j.cn311847-20210607-00179
- VernacularTitle:高压氧辅助放射性 131I治疗老年甲亢患者疗效分析
- Author:
Ziwen LIU
1
;
Yang LIU
1
;
Zhiqiang YANG
1
;
Tao ZHOU
1
;
Fengzhen ZHANG
1
Author Information
1. 商丘市第一人民医院核医学科，商丘 476000
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Radioactive iodine 131;
Senile hyperthyroidism;
Thyroid hormone
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(1):43-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the curative effect of radioactive 131I therapy assisted by hyperbaric oxygen（HBO）on elderly patients with hyperthyroidism. Methods:A total of 185 elderly patients with hyperthyroidism diagnosed and treated in the First People’s Hospital of Shangqiu，Henan Province，from January 2015 to December 2019 were divided into control group（91 cases）and experimental group（94 cases）according to different treatment methods. The control group was treated with radioactive 131I，while the experimental group received HBO as an auxiliary treatment on the basis of the treatment of the control group. The World Health Organization Quality of Life Measurement Scale（WHO-QOL）was used to evaluate the quality of life. The clinical efficacy，complications，occurrence of hypothyroidism，recurrence of hyperthyroidism，thyroid hormone levels before and after treatment，and quality of life were compared between the two groups. Results:The total effective rate of treatment in the experimental group（90.43%）was significantly higher than that in the control group（76.92%， P<0.05）. After treatment，the levels of free triiodothyronine（FT3），free thyroxine（FT4），thyroglobulin autoantibodies（TGAb），and thyroid peroxidase antibodies（TPOAb）all decreased in both groups（ P<0.05），and these levels in the experimental group were significantly lower than those in the control group（ P<0.05）. After treatment，the levels of thyroid stimulating hormone（TSH）in both groups increased（ P<0.05），and the level in the experimental group was significantly higher than that in the control group（ P<0.05）. After treatment，the scores pertaining to physical health，mental state，personal belief，social relationship，environment，and level of independence in the two groups all increased（ P<0.05），and the scores in the experimental group were all significantly higher than those in the control group（ P<0.05）. The incidences of complications（3.19% vs. 5.49%）and hypothyroidism（10.64% vs. 13.19%），and hyperthyroidism recurrence rates（2.13% vs. 3.30%）in both groups were not significantly different from each other（ P>0.05）. Conclusion:HBO-assisted radioactive 131I therapy in elderly patients with hyperthyroidism can effectively increase the level of thyroid hormones，the quality of life，and treatment efficacy，without increasing the incidences of complications and hypothyroidism，and the recurrence of hyperthyroidism.
