Epidemiological investigation on the prevalence of hyperuricemia and urinary calculi in tropical island population
10.3760/cma.j.cn311847-20210607-00178
- VernacularTitle:热带海岛人群高尿酸血症与泌尿系结石的流行病学调查
- Author:
Wei ZHANG
1
;
Bin YANG
;
Haowei LI
;
Xiaolei SHI
;
Chen YE
;
Manjiao LIU
Author Information
1. 海军军医大学第一附属医院泌尿外科，上海 200433
- Publication Type:Journal Article
- Keywords:
Tropical islands;
Hyperuricemia;
Gout;
Urinary calculi;
Risk factors
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(2):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of hyperuricemia in tropical island population，and to analyze the risk factors of urinary calculi in patients with hyperuricemia or gout.Methods:A total of 638 samples of tropical island people who received annual physical examinations were the subjects of our study. Their general information，renal function indicators，and urological ultrasound data were collected. The intergroup comparison and binary Logistic regression were applied for statistical analysis.Results:The incidences of hyperuricemia and gout were 36.4% and 1.3%，respectively，in tropical island population. The incidences of urinary calculi in cases with normal uric acid，asymptomatic hyperuricemia，and gout were 14.3%，23.9%，and 72.7%，respectively. A positive correlation was found between serum creatinine and uric acid levels among the 638 cases（ r = 0.25， P < 0.001），and the level of urea nitrogen increased slightly with the increase of uric acid（ r = 0.07， P = 0.051）. The elevated serum uric acid（ OR = 1.0， P = 0.013）and history of gout（ OR = 7.9， P = 0.004）were risk factors for the occurrence of urinary calculi in tropical island population. The combination of these two parameters could predict the occurrence of urinary calculi with AUC = 0.601，which was slightly better than using serum uric acid level alone with AUC = 0.598（ P = 0.158）. Conclusion:The proportion of patients with hyperuricemia in tropical islands is significantly higher than that in non-tropical regions. The serum creatinine and urea nitrogen levels are positively correlated with uric acid levels among the cases. The elevated serum uric acid and history of gout are risk factors for the occurrence of urinary calculi in tropical island population. The combination of these two parameters has a certain role in predicting the occurrence of urinary calculi.
