Predictive value of dynamic changes in serum SCr and cTnI levels for heart failure in emergency STEMI patients after interventional treatment
10.3969/j.issn.1008-0074.2025.03.11
- VernacularTitle:血清SCr、cTnI水平动态变化对急诊STEMI患者介入治疗后心力衰竭发生的预测价值
- Author:
Jing TAN
1
;
Xu CHEN
1
Author Information
1. 苏州市第九人民医院临床检验科,江苏苏州 215200
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Heart failure;
Creatinine;
Troponin I
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(3):338-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of dynamic changes in serum creatinine(SCr)and cardiac troponin I(cT-nI)levels in predicting the occurrence of heart failure in emcrgency patients with ST segment elevation myocardial in-farction(STEMI)after interventional treatment.Methods:A total of 186 patients with emergency STEMI admitted to Suzhou Ninth People's Hospital between January 2021 and January 2023 were enrolled and followed up for 1 year to record the incidence of heart failure.Receiver operating characteristic(ROC)curves were plotted to determine the optimal cut-off points of Scr,△SCr(absolute value of SCr on 7d after operation-baseline SCr),cTnI,and △cTnI(absolute value of cTnI on 7d after operation-baseline cTnI),and the value of each indicator in predicting heart failure.Results:After 1-year follow-up,the incidence of heart failure after percutaneous coronary intervention(PCI)was 27.78％(50/180).Compared with patients in no occurrence group,those in occurrence group had significant highcr △SCr[18.45(9.01,34.17)μmol/L vs.2.15(0.76,6.45)μmol/L],△cTnI[1.52(0.72,2.71)μg/L vs.0.56(0.15,1.43)μg/L](P＜0.001 all).ROC curve indicated that the optimal cut-off points of SCr,△SCr,cTnI and △cTnI were 113.235 μmol/L,8.595μmol/L,8.475 μg/L and 0.695μg/L,respectively.Multivariate Logistic regression analysis showed that baseline SCr≥113.235μmol/L,△SCr ≥8.595μmol/L,baseline cTnI ≥8.475 μg/L and △cTnI ≥0.695μg/L were independent risk factors for heart failure after PCI in emergency STEMI patients(OR=3.480～21.035,P＜0.01 all).Pearson correlation analysis indicated that baseline SCr was significantly positive associated with baseline cTnI(r=0.232,P=0.002).Conclu-sion:The dynamic changes of serum SCr and cTnI levels may predict the occurrence of heart failure in STEMI patients af-ter interventional treatment.
