Correlation Analysis of LysoPC,Tau,GDF-10 Levels and Prognosis in Oral Squamous Cell Carcinoma
10.3870/j.issn.1672-0741.24.08.042
- VernacularTitle:LysoPC、Tau与GDF-10在口腔鳞状细胞癌中的表达水平及预后相关性分析
- Author:
Jiang ZHU
1
;
Donghui SONG
;
Xueming YANG
Author Information
1. 江苏省南通大学附属医院口腔科,南通 226001
- Publication Type:Journal Article
- Keywords:
lysophosphatidylcholine;
microtubule associated protein Tau;
growth differentiation factor-10;
oral squa-mous cell carcinoma;
prognosis
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(1):90-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of lysophosphatidylcholine(LysoPC),microtubule associated pro-tein Tau(MAPT)and growth differentiation factor-10(GDF-10)in oral squamous cell carcinoma(SCC),and their correlation with prognosis.Methods In all,128 patients with oral squamous cell carcinoma who visited Nantong University Affiliated Hos-pital from April 2017 to April 2019 were selected as the study group,and 100 patients with benign oral lesions during the same time period were selected as the control group.The expression levels of LysoPC,Tau and GDF-10 were compared between the 2 groups of patients.The relationship between the expression levels of LysoPC,Tau,GDF-10,the clinical staging,lymph node me-tastasis,and survival of oral squamous cell carcinoma patients were analyzed,and the assessment values of these factors for prognosis were evaluated.Results The positive rate of Tau and GDF-10 in pathological tissue and LysoPC in serum of the stud-y group were lower than those of the control group(all P＜0.05).Patients with low expression levels of LysoPC,Tau and GDF-10 had a higher proportion of stage Ⅲ to Ⅳ and lymph node metastasis than those with high expression levels of LysoPC,Tau and GDF-10(all P＜0.05).The 128 patients were followed up for 5 years,86 survived(67.19％),42 died(32.81％).LysoPC,Tau and GDF-10 levels were negatively correlated with survival time(all P＜0.05,r=-0.597,-0.622,-0.656).The results of log-rank test showed that the 5-year survival rate of LysoPC,Tau and GDF-10 low expression group was lower than that of LysoPC,Tau and GDF-10 high expression group(all P＜0.05).The high expression levels of LysoPC,Tau and GDF-10 were protective factors,while lymph node metastasis and high clinical stage were risk factors(all P＜0.05).Conclusion LysoPC,Tau and GDF-10 are all low expressed in patients with oral squamous cell carcinoma,and the expression level is correlated with clinical stage and lymph node metastasis.Low expression may indicate a higher risk of death.
