Effects of diphenhydramine and caffeine compound on motion sickness
10.3760/cma.j.cn311847-20210104-00002
- VernacularTitle:苯海拉明咖啡因复方抗运动病的实验研究
- Author:
Jie LUAN
1
;
Huijie NING
;
Lin ZHU
;
Zhonglan YUAN
;
Yan ZHOU
;
Xinhao XING
;
Zhiyong CHU
;
Yan WANG
Author Information
1. 200433 上海，海军军医大学特色医学中心
- Publication Type:Journal Article
- Keywords:
Diphenhydramine and caffeine compound;
Motion sickness;
SD rat;
Beagle dog
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(6):707-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of diphenhydramine and caffeine compound on motion sickness.Methods:Sixty Sprague Dawley (SD) rats were randomly divided into six groups with ten rats in each group, namely, blank control group, model control group, diphenhydramine group (2.25 mg/kg), compound (diphenhydramine and caffeine) low-dose group [(1.13+ 2.70) mg/kg], compound medium-dose group [(2.25+ 5.40) mg/kg], and compound high-dose group [(4.50+ 10.80) mg/kg]. The mental states of rats were observed. The motion sickness (MS) scores and saccharin water intake were evaluated. Thirty Beagle dogs were randomly divided into five groups with six dogs in each group, namely, model control group, diphenhydramine group (0.67 mg/kg), compound (diphenhydramine and caffeine) low-dose group [(0.33+ 0.80) mg/kg], compound medium-dose group [(0.67+ 1.60) mg/kg], and compound high-dose group [(1.34+ 3.20) mg/kg]. The latent periods of salivation and vomiting after rotational stimulation were observed and recorded.Results:The rats in the compound medium-dose group and the compound high-dose group did not manifest somnolence while the rats in other groups receiving diphenhydramine did. After rotational stimulation, the MS scores of the rats in the model group were higher than those of the rats in the compound groups, and the MS scores in the compound groups showed a dose-dependent decreasing trend. Before rotational stimulation, there were no significant difference in the saccharin water intake among the rats of all the groups. After rotational stimulation, the saccharin water intake in the model group was more significantly reduced than that of the blank control group ( P<0.01). Compared with the model group, the saccharin water intakes in diphenhydramine group and compound groups were significantly increased ( P<0.05), and the increase were dose-dependent. Before drug administration, all the Beagle dogs were susceptible to rotational stimulation with early salivation and vomiting. After drug administration, the latent periods of salivation and vomiting were all considerably extended ( P<0.05), and the extension of the latent periods in the compound groups was dose-dependent. Conclusion:The diphenhydramine and caffeine compound has protective effects against motion sickness, and the adverse reactions of inhibition in central nervous system are mild.
