The correlation between serum chitinase 1 and secreted crimp-associated protein 5 and renal function indexes in patients with diabetic kidney disease
10.3760/cma.j.cn115455-20241112-00991
- VernacularTitle:糖尿病肾脏疾病患者血清几丁质酶1、分泌型卷曲相关蛋白5水平与肾功能指标的相关性研究
- Author:
Yang ZHAO
1
;
Xusheng YANG
1
;
Yanping PENG
1
Author Information
1. 首都医科大学附属北京康复医院肾内科，北京 100144
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Chitinase 1;
Secretory crimp-associated protein 5;
Kidney function tests
- From:
Chinese Journal of Postgraduates of Medicine
2025;48(6):543-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between serum chitinase 1 (CHIT1), secreted crimp-associated protein 5 (SFRP5) and renal function in patients with diabetic kidney disease (DKD).Methods:Two hundred patients with DKD (observation group) and 180 patients with simple diabetes (control group) diagnosed and treated in Beijing Rehabilitation Hospital Affiliated to Capital Medical University from July 2022 to July 2024 were retrospectively selected. Oxidative stress indexes, glucose and lipid metabolism indexes, renal function indexes, CHIT1 and SFRP5 levels of the two groups were detected. Multivariate Logistic regression was used to analyze the risk factors of DKD in diabetic patients, and Pearson test was used to analyze the correlation between serum CHIT1 and SFRP5 levels and renal function indexes.Results:The levels of CHIT1 and SFRP5 in the observation group were higher than those in the control group : (1.25 ± 0.29) μg/L vs. (0.90 ± 0.22) μg/L, (10.91 ± 3.21) μg/L vs. (5.70 ± 1.17) μg/L, there were statistical differences ( P<0.05). The results of Multivariate Logistic regression analysis showed that fasting blood glucose, glycated hemoglobin, postprandial 2 h blood glucose, total cholesterol, low density lipoprotein cholesterol, triacylglycerol, high density lipoprotein cholesterol, steady-state model insulin resistance index, steady-state model islet beta cell function index, advanced oxidized protein products, malondialdehyde, superoxide dismutol, total antioxidant capacity, cystatin C (CysC), urea nitrogen (BUN), serum creatinine (SCr), isotype cysteine (Hcy), glomerular filtration rate (GFR), CHIT1 and SFRP5 were all risk factors for DKD ( P<0.05). Pearson test results showed that serum CHIT1 and SFRP5 levels in DKD patients were positively correlated with CysC, BUN, SCr and Hcy levels ( r = 0.669, 0.708, 0.558, 0.537 and 0.619, 0.559, 0.639, 0.555, P<0.01), and there were negative correlation with GFR level ( r = - 0.558, -0.363, P<0.01). Conclusions:Serum CHIT1 and SFRP5 levels in DKD patients are significantly increased, which are related to renal function indicators. Changes in serum CHIT1 and SFRP5 levels can reflect the degree of renal function injury and can be used as auxiliary clinical indicators for disease monitoring.
