Study on clinical characteristics and polysomnography results of patients with co-morbid insomnia and obstructive sleep apnea
10.3969/j.issn.1002-0152.2025.06.003
- VernacularTitle:失眠共病阻塞性睡眠呼吸暂停患者的临床及多导睡眠图特征研究
- Author:
Yali XU
1
;
Zhaoyang HUANG
Author Information
1. 首都医科大学宣武医院神经内科,北京神经调控重点实验室(北京 100053);福建省莆田市第一医院神经内科,福建医科大学临床医学部
- Publication Type:Journal Article
- Keywords:
Co-morbid insomnia and obstructive sleep apnea;
Insomnia;
Obstructive sleep apnea;
Polysomnogra-phy;
Clinical characteristics;
Sleep quality;
Sleep structure
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(6):335-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective Compared with patients with insomnia,the clinical characteristics and polysomnography(PSG)results from patients with co-morbid insomnia and obstructive sleep apnea(COMISA)were analyzed.The analysis was conducted to investigate clinical manifestations,sleep physiological characteristics,and related risk factors of COMISA patients.Methods A total of 134 patients with insomnia were enrolled and divided into two groups based on whether their apnea-hypopnea index(AHI)was≥5 events/hour:the COMISA group(69 patients)and the insomnia-only group(65 patients).The COMISA group was further divided into a mild OSA subgroup of 41 cases and a moderate-to-severe OSA subgroup of 28 cases;and then into a mild insomnia subgroup of 37 cases and a moderate-to-severe insomnia subgroup of 32 cases.The demographic characteristics,Pittsburgh sleep quality index(PSQI),self-rating depression scale(SDS),self-rating anxiety scale(SAS),Epworth sleepiness scale(ESS)and PSG results were analyzed.Results Compared with the insomnia-only group,the COMISA group had a higher proportion of men,a higher age,a higher body mass index(BMI),a higher proportion of smoking,a higher proportion of snoring,a lower average blood oxygen saturation and lowest blood oxygen saturation,a higher proportion of N2 stage,and a lower proportion of N3 stage and R stage(P<0.05).Compared with the mild OSA subgroup,the moderate-to-severe OSA subgroup had a higher BMI index,a higher proportion of snoring,a higher SAS score,a lower average blood oxygen saturation and lowest blood oxygen saturation,a higher proportion of N1 stage,and a lower proportion of N3 stage(P<0.05).Compared with the subgroup of mild insomnia,the subgroup of moderate-to-severe insomnia in the COMISA group had a higher proportion of hypnotic drug use(P<0.01),but there was no significant difference between the two groups in PSG results(P>0.05).Logistic regression analysis showed that older age(OR=1.07,P<0.01)and higher BMI(OR=1.41,P<0.01)were risk factors for the co-occurrence of OSA in insomnia patients.Conclusion Patients with COMISA have worse objective sleep quality at night than those with insomnia-only,and patients with more severe OSA have poorer objective sleep quality.In clinical practice,it is important to be aware of the risk of comorbid OSA for patients with insomnia who are older and have a higher BMI.
