Association of MUFAs and PUFAs intake with risk of non-alcoholic fatty liver disease:a secondary analysis based on Dryad data
- VernacularTitle:单不饱和脂肪酸和多不饱和脂肪酸摄入量与非酒精性脂肪性肝病风险的相关性:一项基于Dryad数据的二次分析
- Author:
Na FENG
1
;
Yang XU
;
Jing JI
;
Di BAI
;
Gen LIU
;
Wenjing ZHU
;
Yafan SONG
;
Yan ZHANG
;
Tuo HAN
Author Information
- Publication Type:Journal Article
- Keywords: non-alcoholic fatty liver disease(NAFLD); monounsaturated fatty acids(MUFAs); polyunsaturated fatty acids(PUFAs); daily intake
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(4):690-697
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the relationship between daily intake of monounsaturated fatty acids(MUFAs)and polyunsaturated fatty acids(PUFAs)and non-alcoholic fatty liver disease(NAFLD),and to determine the threshold values of daily MUFAs and PUFAs intake for NAFLD risk.Methods Date were collected from the Dryad database.We enrolled a total of 1 068 healthy subjects aged 18 years and older(534 in the control group and 534 with NAFLD group)who had physical check-up in the Affiliated Nanping First Hospital of Fujian Medical University from April 2015 to August 2017.Comprehensive medical histories were obtained through questionnaires;information on dietary intake was collected using a semi-quantitative food frequency questionnaire and daily MUFAs and PUFAs intake were calculated.Baseline characteristics were compared between the two groups,and Logistic regression and restricted cubic spline(RCS)analyses were used to explore the relationship between daily MUFAs or PUFAs intake and NAFLD.Results Compared with the control group,the prevalence of hypertension,tea drinking,body mass index(BMI),daily energy intake,and daily MUFAs and PUFAs intakes were significant higher in patients with NAFLD(all P＜0.05),but the proportion of physical activities was significantly lower(P＜0.05).Logistic regression analysis revealed that after adjusting other confounding factors such as age,gender and BMI,for every 10 g increase in daily MUFAs or PUFAs intake,the risk of NAFLD increased by 53％(95％ CI:1.25-1.87,P＜0.001)and 3.30 times(95％ CI:2.98-6.20,P＜0.001),respectively.RCS indicated an approximately linear relationship between daily MUFAs intake and NAFLD(P for nonlinearity=0.064)and a nonlinear relationship between daily PUFAs intake and NAFLD(P for nonlinearity＜0.05).Subgroup analysis results were generally consistent,and there was statistical evidence of interactions between MUFAs and factors such as gender,hypertension and education level,with interaction between PUFAs and BMI observed(P＜0.05).Conclusion Increased daily intake of MUFAs or PUFAs is significantly associated with an increased risk of NAFLD,and further research is needed to clarify their specific roles in hepatic lipid accumulation.
