The Interaction Between NETs and Immune Cells in Autoimmune Diseases
10.3870/j.issn.1672-0741.24.09.001
- VernacularTitle:自身免疫性疾病中NETs与免疫细胞的相互作用
- Author:
Ran GAO
1
;
Chenyu LIU
;
Chaohua DENG
Author Information
1. 华中科技大学同济医学院附属同济医院眼科,武汉 430030
- Publication Type:Journal Article
- Keywords:
neutrophil extracellular traps;
dendritic cell;
macrophage;
B cell;
CD4+T cell;
autoimmune disease
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(1):129-136
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,our understanding of neutrophil extracellular traps(NETs)has been deepened with advancements in technology.Extensive research has demonstrated that NETs are intricately linked to autoimmunity and contribute to the path-ogenesis of autoimmune diseases through multiple mechanisms,such as serving as a source of self-antigens,activating the com-plement system,or modulating other immune cells.Notably,the interaction between NETs and immune cells plays a critical role in disease progression.This article primarily reviews the relationship of NETs with dendritic cells,macrophages,B cells,and CD4 T cells in autoimmune diseases,providing insights into potential therapeutic strategies by NETs level modulation and NETs-immune cell interactions intervenion.
