The Role of Platelet in Acute Kidney Injury
10.3870/j.issn.1672-0741.24.09.024
- VernacularTitle:血小板在急性肾损伤中作用的研究进展
- Author:
Wenli XIONG
1
;
Yun XU
;
Xiangbin ZENG
Author Information
1. 华中科技大学同济医学院附属梨园医院职工保健科,武汉 430062
- Publication Type:Journal Article
- Keywords:
acute kidney injury;
immune response;
platelet release;
drug target
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(1):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Currently,there is a paucity of efficacious treatments for acute kidney injury(AKI),and existing therapeutic ap-proaches primarily aim to mitigate symptoms and enhance patient outcomes.Platelets,a vital element of the circulatory system,are characterized by their abundance and multifaceted functions.Moreover,several studies have documented platelet infiltration within the kidneys during A KI,revealing elevated expression levels of platelet activation markers such as P-selectin,RANTES,and integrin α Ⅱ bβ3.This suggests that platelet activation occurs in A KI and may influence the progression of the disease.Furthermore,preliminary findings from both clinical and animal model studies indicate that antiplatelet therapy could re-duce tissue damage and protect renal function in AKI resulting from various etiologies.This review aims to elucidate the role of platelets in the pathophysiology of AKI by synthesizing current researches,while also investigating the potential of antiplatelet therapy as a novel approach for the management of AKI,thereby offering new diagnostic and therapeutic strategies.
