Recent advances in diagnosis and management of drug-associated IgA nephropathy
- VernacularTitle:药物相关性IgA肾病的诊疗新进展
- Author:
Ruike CHEN
1
;
Jiali WEI
1
Author Information
- Publication Type:Journal Article
- Keywords: drug-induced kidney injury; IgA nephropathy(IgAN); diagnosis and treatment; mechanism; advances
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2025;46(4):715-720
- CountryChina
- Language:Chinese
- Abstract: Drug-associated IgA nephropathy(DA-IgAN)is an important subtype of secondary IgA nephropathy(sIgAN),with insidious clinical manifestations and highly overlapping pathological features with primary IgA nephropathy(IgAN),leading to a high risk of misdiagnosis.The disease's pathogenesis is complex and involves a variety of drugs.Non-steroidal anti-inflammatory drugs and antibiotics were the most common in the past.Recent studies have revealed that a variety of drugs[such as tumor necrosis factor-α(TNF-α)inhibitors,interleukin-12/interleukin-23(IL-12/IL-23)inhibitors,immune checkpoint inhibitors(ICIs),cytotoxic T-lymphocyte associated antigen 4(CTLA-4)inhibitors,oral anticoagulants,thiourea derivatives,and anti-vascular endothelial growth factors]may trigger or aggravate IgAN through different mechanisms.This article summarizes the pathogenic drugs,mechanisms,diagnosis,and treatment progress of drug-induced IgAN,providing some evidence for improved clinical diagnosis and management.
