Effects of hyperbaric oxygen on the clinical efficacy and prognosis of severe viral encephalitis in children
10.3760/cma.j.cn311847-20210104-00001
- VernacularTitle:高压氧对小儿重症病毒性脑炎的临床疗效及预后的影响
- Author:
Manqiu CHEN
1
;
Chunfeng YANG
;
Xun GUO
;
Yumei LI
Author Information
1. 130021 长春，吉林大学第一医院高压氧科
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Children;
Viral encephalitis
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of hyperbaric oxygen therapy on the clinical efficacy and prognosis of severe viral encephalitis (VE) in children.Methods:The clinical data of 83 children with severe VE treated in the Pediatric Intensive Care Unit (PICU) of the First Hospital of Jilin University from January 2013 to December 2017 were analyzed retrospectively. They were divided into two groups according to different treatment methods, namely control group (conventional treatment) and treatment group (conventional treatment combined with hyperbaric oxygen therapy). The clinical efficacy of the two groups after 30 days of treatment were compared. The prognosis of children with limb paralysis in the observation group after 30 days of hyperbaric oxygen treatment was compared with that of the control group at the same time point.Results:The total effective rate of the treatment group (85.4%) was significantly higher than that of the control group (71.9%) ( χ2=7.114, P<0.05). The signs and symptoms of fever, convulsion, coma, delirium, cranial nerve involvement, and meningeal irritation of the treatment group recovered earlier than those of the control group ( P<0.05). After treatment, the limb function scores of children with limb paralysis in the treatment group were significantly higher than those in the control group ( P<0.05). The improvement rate of brain lesions on MRI in the treatment group (86.5%) was significantly higher than that in the control group (71.9%) (χ 2=6.138, P<0.05). Conclusion:The treatment combined with hyperbaric oxygen can shorten the duration of clinical symptoms and signs of children with severe VE, significantly improve the brain lesions on MRI, accelerate the recovery of limb dyskinesia, and shorten the length of hospital stay.
