Genetic Correlation Between Autoimmune Liver Disease and Type 1 Diabetes:A Mendelian Randomization Study
10.3870/j.issn.1672-0741.24.08.030
- VernacularTitle:自身免疫性肝病和1型糖尿病之间的遗传联系:一项两样本孟德尔随机化研究
- Author:
Shuyu SHAO
1
;
Xing ZHOU
1
;
Zifang SONG
1
Author Information
1. 华中科技大学同济医学院附属协和医院肝胆外科,武汉 430022
- Publication Type:Journal Article
- Keywords:
autoimmune liver disease;
type 1 diabetes;
Mendelian randomization;
bidirectional causal association
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(1):22-29,100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential causal relationship between autoimmune liver diseases(AILD)and type 1 diabetes(T1D)based on two-sample Mendelian randomization(TSM R)method.Methods Genome-wide association study(GWAS)data were obtained from the Open GWAS database.Forward Mendelian randomization analysis was performed with three types of AILD as exposures and T1D as the outcome,while reverse analysis was conducted with T1D as the exposure and three types of AILD as outcomes.Single nucleotide polymorphism(SNP)that was significantly associated with the exposure was selected as instrumental variable(IV).The inverse variance weighting(IVW)method was employed as the primary analytical ap-proach to explore the bidirectional causal relationships between AILD and T1D.Sensitivity analyses,including heterogeneity tests and horizontal pleiotropy tests,were conducted to ensure the robustness of the results.Results The IVW analysis indica-ted that primary biliary cholangitis(PBC)increased the risk of T1D(OR=1.14,95％CI:1.082-1.201,P=9.41 ×10-7),while no significant associations was observed for primary sclerosing cholangitis(PSC)and autoimmune hepatitis(AIH)with T1D(PSC:OR=1.058,95％CI:0.966-1.159,P=0.223;AIH:OR=0.992,95％CI:0.953-1.033,P=0.706).Conversely,T1D was associated with an increased risk of PBC(OR=1.272,95％CI:1.143-1.416,P=1.024×10-5)and PSC(OR=1.246,95％CI:1.072-1.448,P=0.004),but not AIH(OR=1.032,95％CI:0.931-1.144,P=0.551).Conclusion This study demon-strates a bidirectional causal relationship between PBC and T1D,and T1D also increases the risk of PSC.These findings provide new insights and directions for future research into the molecular mechanisms underlying these associations.
