Effect of early and full course of hyperbaric oxygen therapy on neuroelectrophysiology in patients with acute incomplete spinal cord injury
10.3760/cma.j.cn311847-20210501-00139
- VernacularTitle:早期足疗程高压氧综合治疗对急性不完全性脊髓损伤患者神经电生理的影响
- Author:
Changhong LIU
1
;
Xiaoyang LIU
;
Shiqiao LYU
;
Quntao YU
;
Jincheng ZHANG
Author Information
1. 264000 山东省烟台，烟台山医院
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Acute incomplete spinal cord injury;
Neuroelectrophysiology
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(5):577-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of early and full course of hyperbaric oxygen (HBO) therapy on neuroelectrophysiology in patients with acute incomplete spinal cord injury (iSCI).Methods:A total of 65 patients with acute iSCI admitted to the Department of Orthopedics of Yantai Mountain Hospital and the Department of Spine Injury of Yuhuangding Hospital from February 2017 to February 2020 were selected as the research objects. According to the treatment, they were divided into observation group ( n=42) and control group ( n=23). The patients in the control group were treated with conventional drugs or surgery, while the patients in the observation group were treated with full course of HBO at early stage (<48 h) on the basis of the treatment in the control group. The scores of Frankel scale and American Spinal Injury Association (ASIA) impairment scale were collected before treatment, and 14 and 28 days after treatment; and the clinical efficacy was evaluated. The motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV), amplitude of sensory action potential (SAP), motor evoked potential (MEP), and somatosensory evoked potential (SEP) of lower limbs were measured and calculated by electromyography and evoked potential meter before treatment, 14 days and 28 days after treatment. Results:After four courses of treatment, the total effective rate of the observation group (85.71%) was significantly higher than that of the control group (69.57%) with a statistically significant difference ( χ 2=6.994, P<0.05). Compared with those before treatment, the scores of neurological and motor functions (ASIA scale and Frankel scale) of the two groups after 14 days of treatment were significantly increased; compared with the scores after 14 days of treatment, the scores of neurological and motor functions after 28 days of treatment were significantly increased; compared with the scores of the control group, the scores of neurological and motor functions of the treatment group were significantly increased; and all of these were statistically significant( P<0.05). Compared with those before treatment, the peak amplitudes of SEP and MEP of tibial nerve and common peroneal nerve in the two groups were increased and the latencies were shortened after 14 days of treatment; compared with those after 14 days of treatment, the peak amplitudes of SEP and MEP of anterior tibial nerve and common peroneal nerve were increased and the latencies were shortened after 28 days of treatment; compared with those in the control group after treatment, the peak amplitudes of SEP and MEP of anterior tibial nerve and common peroneal nerve in the observation group after treatment were increased and the latencies were shortened; and all of these were statistically significant( P<0.05). Compared with those before treatment, the SCV and MCV of tibial nerve and common peroneal nerve in the two groups were significantly increased after 14 days of treatment; compared with those after 14 days of treatment, the SCV and MCV of anterior tibial nerve and common peroneal nerve were significantly increased after 28 days of treatment; compared with those in the control group after treatment, the SCV and MCV of anterior tibial nerve and common peroneal nerve in the observation group after treatment were significantly increased ( P<0.05); and all of these were statistically significant( P<0.05). Conclusion:For patients with acute iSCI, early and full course of HBO therapy can significantly improve their neuro-bioelectricity such as motor, sensory, and other evoked potentials, improve the clinical efficacy, and facilitate the recovery of spinal nerve function.
