Predictive value of systemic immune-inflammation index for the severity of post endoscopic retrograde cholangiopancreatography pancreatitis in elderly patients
- VernacularTitle:全身免疫炎症指数预测老年患者内镜逆行胰胆管造影术后胰腺炎的价值研究
- Author:
Weiwei HAN
1
;
Weizhao WANG
1
;
Chao SUN
1
;
Chaowu CHEN
1
;
Jun LIU
1
Author Information
- Publication Type:Journal Article
- Keywords: endoscopic retrograde cholangiopancreatography (ERCP); elderly; pancreatitis; systemic immune-inflammation index (SII)
- From: China Journal of Endoscopy 2024;30(12):55-60
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the predictive value of systemic immune-inflammation index (SII) on the clinical prognosis of elderly patients with severe post endoscopic retrograde cholangiopancreatography pancreatitis (PEP).Methods From January 2020 to December 2022,189 elderly patients (aged ≥ 60 years) who developed PEP were evaluated retrospectively.Patients were divided into normal group (n=98),mild-to-moderate PEP group (n=79) and severe PEP group (n=12) according to whether pancreatitis occurred and the severity of pancreatitis based on the prolongation of planned hospitalization.Then compare the levels of SII in each group,analyze the correlation of the SII levels and severity of PEP.Receiver operator characteristic curve (ROC curve) was used to analyze the predictive value for PEP severity in the elderly.Results Compared to the normal group,the mild-to-moderate PEP group and severe PEP group had significantly higher level of blood cell count and SII level stay on 24 and 48 h after ERCP,longer length of hospital,but the serum calcium level was lower,the differences were statistically significant (P<0.05).The SII level and bedside index for severity in acute pancreatitis (BISAP) score were higher in the severe PEP group compared with the mild-to-moderate PEP group,the length of hospital stay was longer in the severe PEP group compared with the mild-to-moderate PEP group,the differences were statistically significant (P<0.05),but there were no significant changes in serum calcium level and white blood cell count.The area under the curve of the SII on 24 and 48 h for severe PEP was 0.68 and 0.94 (P<0.05),respectively.The prediction of severe PEP was 1490.51 (sensitivity was 83％,specificity was 57％) and 1686.97 (sensitivity was 91％,specificity was 89％),respectively.Conclusion SII can predict the severity of PEP in elderly patients,and SII on 48 h post-ERCP is a reliable prognostic marker of severe PEP.
